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Article

Differential associations between apolipoprotein E alleles and cerebral myelin content in normative aging.

NeuroImage - 1 May 2022

Triebswetter Curtis, Kiely Matthew, Khattar Nikkita, Ferrucci Luigi, Resnick Susan M, Spencer Richard G, Bouhrara Mustapha

Abstract excerpt

Mounting evidence indicates that myelin breakdown may represent an early phenomenon in neurodegeneration, including Alzheimer's disease (AD). Understanding the factors influencing myelin synthesis and breakdown will be essential for the development and evaluation of therapeutic interventions. In this work, we assessed associations between genetic variance in apolipoprotein E (APOE) and cerebral myelin content....

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Identifiers

PMID: 35150834
DOI: 10.1016/j.neuroimage.2022.118988
PMCID: PMC8940662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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