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Article

Brain myelin water fraction is associated with APOE4 allele status in patients with cognitive impairment.

Journal of neuroimaging : official journal of the American Society of Neuroimaging - 1 May 2022

Park Mina, Lee Hong Pyo, Kim Junghyeob, Kim Dong Hyun, Moon Yeonsil, Moon Won-Jin

Abstract excerpt

BACKGROUND AND PURPOSE: Apolipoprotein E4 (APOE4) is a major genetic risk factor for Alzheimer's disease. However, the effect of APOE4 status on myelin remains unclear. This study investigated the effect of APOE4 on myelin content in cognitively impaired individuals using T2* gradient echo (GRE)-based myelin water fraction (MWF) imaging. METHODS: Between August 2017 and January 2019, we evaluated 39 cognitively...

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PMID: 34964524
DOI: 10.1111/jon.12960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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