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Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer’s disease

2024-08-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> White matter (WM) alterations are among the earliest changes in Alzheimer’s disease (AD), yet limited work has comprehensively characterized the effects of AD risk factors on WM. <h4>METHODS</h4> In older adults with a family history of AD, we investigated the sex-specific and APOE genotype-related relationships between WM microstructure and risk factors. Multiple MRI-der...

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Literature Corpus work
142d487b-89b3-5ab6-aeb2-f07756972f7a
DOI
10.1101/2024.08.21.608995
Open publication

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Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer’s diseaseDOI 10.1101/2024.08.21.608995
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