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Article

APOE ε4 allele accelerates age-related multi-cognitive decline and white matter damage in non-demented elderly.

Aging - 22 Jun 2020

Sun Jinping, Zhu Zhibao, Chen Kewei, Wei Dongfeng, Li Xin, Li He, Zhang Junying, Chen Xiaochun, Chen Yaojing, Zhang Zhanjun

Abstract excerpt

Advanced age and apolipoprotein E (APOE) ε4 allele are both associated with increased risk of the Alzheimer's disease (AD). However, the extent of the joint contribution of APOE ε4 allele and age on the brain white matter integrity, cognition and their relationship are unclear. We assessed the age-related variation differences of major cognitions in 846 non-demented elderly, and brain major white matter tracts in...

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Identifiers

PMID: 32572010
DOI: 10.18632/aging.103367
PMCID: PMC7343443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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