Article
MRI of carriers of the apolipoprotein E e4 allele-evidence for structural differences in normal-appearing brain tissue in e4+ relative to e4- young adults.
NMR in biomedicine - 1 Jun 2013
Dowell Nicholas G, Ruest Torsten, Evans Simon L, King Sarah L, Tabet Naji, Tofts Paul S, Rusted Jennifer M
Abstract excerpt
Apolipoprotein E is a protein involved in cholesterol and lipid transport. The gene coding for this protein has three different alleles: e2, e3 and e4. The e4 allele is recognised as a significant risk factor for the development of Alzheimer's disease in later life. Paradoxically, behavioural and functional evidence has demonstrated that the e4 allele may confer a cognitive advantage to the carrier in youth. In...
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