Article
The contribution of human leucocyte antigen complex genes to disease phenotype in ulcerative colitis.
Tissue antigens - 1 Dec 2003
Ahmad T, Armuzzi A, Neville M, Bunce M, Ling K-L, Welsh K I, Marshall S E, Jewell D P
Abstract excerpt
Linkage and association studies implicate the human leucocyte antigen (HLA) region in genetic susceptibility to ulcerative colitis (UC). However, associations with specific variants have been inconsistent, even within defined ethnic groups. A genetic basis for the disease heterogeneity of UC may account for these discrepant findings from studies in unselected populations. Here, we examine the contribution of the...
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