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Article

HLA in coeliac disease: Unravelling the complex genetics of a complex disorder

1 Feb 2003

Abstract excerpt

Coeliac disease (gluten sensitive enteropathy) is a common, polygenic and multifactorial disorder that serves as a pioneering model for the study of inflammatory disease. A major environmental factor is known (ingested gluten from wheat), and there is unprecedented genetic and functional evidence pinpointing HLA-DQA1*05-DQB1*02 ( DQ2) and DQA1*03-DQB1*0302 ( DQ8) in disease predisposition. We discuss the current...

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PMID: 12694579
DOI: 10.1034/j.1399-0039.2003.00017.x

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