The contribution of HLA genes to IBD susceptibility and phenotype.

doi:10.1016/j.bpg.2004.01.003

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Article

The contribution of HLA genes to IBD susceptibility and phenotype.

Best practice & research. Clinical gastroenterology - 1 Jun 2004

Yap Lee Min, Ahmad Tariq, Jewell Derek P

Abstract excerpt

The human leukocyte antigen (HLA) region located on chromosome 6p encodes the highly polymorphic, classical class I and II genes essential for normal lymphocyte function; it also encodes a further 224 genes. Many early studies investigating this region were limited by small sample size, poor statistical methodology, population stratification and variable disease definition. Although more recent studies have...

Topics

Colitis, Ulcerative
Crohn Disease
Genetic Linkage
Genetic Predisposition to Disease
HLA Antigens
Heat-Shock Proteins
Humans
Lymphotoxin-alpha
Major Histocompatibility Complex
Phenotype
Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 15157829
DOI: 10.1016/j.bpg.2004.01.003

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