Article
The contribution of HLA genes to IBD susceptibility and phenotype.
Best practice & research. Clinical gastroenterology - 1 Jun 2004
Yap Lee Min, Ahmad Tariq, Jewell Derek P
Abstract excerpt
The human leukocyte antigen (HLA) region located on chromosome 6p encodes the highly polymorphic, classical class I and II genes essential for normal lymphocyte function; it also encodes a further 224 genes. Many early studies investigating this region were limited by small sample size, poor statistical methodology, population stratification and variable disease definition. Although more recent studies have...
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