Article
Genetics of inflammatory bowel disease: the role of the HLA complex.
World journal of gastroenterology - 21 Jun 2006
Ahmad Tariq, Marshall Sara-E, Jewell Derek
Abstract excerpt
The human leucocyte antigen (HLA) complex on chromosome 6p21.3 is the most extensively studied genetic region in Inflammatory bowel disease (IBD). Consistent evidence of linkage to IBD3 (6p21.1-23), an area which encompasses the HLA complex, has been demonstrated for both Crohn's disease and ulcerative colitis, and a number of replicated associations with disease susceptibility and phenotype have recently...
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