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Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

28 May 2019

Abstract excerpt

Recent history is punctuated by the emergence of highly pathogenic coronaviruses such as SARS- and MERS-CoV into human circulation. Upon infecting host cells, coronaviruses assemble a multi-subunit RNA-synthesis complex of viral non-structural proteins (nsp) responsible for the replication and transcription of the viral genome. Here, we present the 3.1 Å resolution structure of the SARS-CoV nsp12 polymerase bound...

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PMID: 31138817
DOI: 10.1038/s41467-019-10280-3

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