Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Life of SARS-CoV-2 Inside Cells: Replication–Transcription Complex Assembly and Function

21 Jun 2022

Abstract excerpt

The persistence of the coronavirus disease 2019 (COVID-19) pandemic has resulted in increasingly disruptive impacts, and it has become the most devastating challenge to global health in a century. The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants challenges the currently available therapeutics for clinical application. Nonstructural proteins (also known as replicase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to PARP inhibition in cancer therapy
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35729072
DOI: 10.1146/annurev-biochem-052521-115653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Life of SARS-CoV-2 Inside Cells: Replication–Transcription Complex Assembly and FunctionPMID 35729072Read ↗

Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug designSemantic proximity Read ↗

Structure and function of SARS-CoV-2 polymeraseSemantic proximity Read ↗

A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final CappingSemantic proximity Read ↗

A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competentSemantic proximity Read ↗

Lessons Learned and Yet-to-Be Learned on the Importance of RNA Structure in SARS-CoV-2 ReplicationSemantic proximity Read ↗

SARS-CoV-2: from its discovery to genome structure, transcription, and replicationSemantic proximity Read ↗

Hallmarks of <i>Alpha</i> - and <i>Betacoronavirus</i> non-structural protein 7+8 complexesSemantic proximity Read ↗

Structure and regulation of coronavirus genomes: state-of-the-art and novel insights from SARS-CoV-2 studiesSemantic proximity Read ↗

Structural biology of SARS-CoV-2: open the door for novel therapiesSemantic proximity Read ↗

An alphacoronavirus polymerase structure reveals conserved co-factor functionsSemantic proximity Read ↗

Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNASemantic proximity Read ↗

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.