Article

Structure of replicating SARS-CoV-2 polymerase

2020-04-27

Abstract excerpt

The coronavirus SARS-CoV-2 uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and the transcription of its genes. Here we present the cryo-electron microscopic structure of the SARS-CoV-2 RdRp in its replicating form. The structure comprises the viral proteins nsp12, nsp8, and nsp7, and over two turns of RNA template-product duplex. The active site cleft of nsp12 binds the first turn of...

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Literature Corpus work: b1803066-a42d-5636-8e28-e9fb673291b1
DOI: 10.1101/2020.04.27.063180

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