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Structure and function of SARS-CoV-2 polymerase

6 Apr 2021

Abstract excerpt

Coronaviruses use an RNA-dependent RNA polymerase (RdRp) to replicate and express their genome. The RdRp associates with additional non-structural proteins (nsps) to form a replication-transcription complex (RTC) that carries out RNA synthesis, capping and proofreading. However, the structure of the RdRp long remained elusive, thus limiting our understanding of coronavirus genome expression and replication....

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PMID: 33945951
DOI: 10.1016/j.coviro.2021.03.010

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