Article
One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2014
Subissi Lorenzo, Posthuma Clara C, Collet Axelle, Zevenhoven-Dobbe Jessika C, Gorbalenya Alexander E, Decroly Etienne, Snijder Eric J, Canard Bruno, Imbert Isabelle
Abstract excerpt
In addition to members causing milder human infections, the Coronaviridae family includes potentially lethal zoonotic agents causing severe acute respiratory syndrome (SARS) and the recently emerged Middle East respiratory syndrome. The ∼30-kb positive-stranded RNA genome of coronaviruses encodes a replication/transcription machinery that is unusually complex and composed of 16 nonstructural proteins (nsps)....
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