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Article

Architecture of a SARS-CoV-2 mini replication and transcription complex.

Nature communications - 18 Nov 2020

Yan Liming, Zhang Ying, Ge Ji, Zheng Litao, Gao Yan, Wang Tao, Jia Zhihui, Wang Haofeng, Huang Yucen, Li Mingyu, Wang Quan, Rao Zihe, Lou Zhiyong

Abstract excerpt

Non-structural proteins (nsp) constitute the SARS-CoV-2 replication and transcription complex (RTC) to play a pivotal role in the virus life cycle. Here we determine the atomic structure of a SARS-CoV-2 mini RTC, assembled by viral RNA-dependent RNA polymerase (RdRp, nsp12) with a template-primer RNA, nsp7 and nsp8, and two helicase molecules (nsp13-1 and nsp13-2), by cryo-electron microscopy. Two groups of mini...

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Identifiers

PMID: 33208736
DOI: 10.1038/s41467-020-19770-1
PMCID: PMC7675986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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