Article

An alphacoronavirus polymerase structure reveals conserved co-factor functions

2023-03-16

Abstract excerpt

Coronaviruses are a diverse subfamily of viruses containing pathogens of humans and animals. This subfamily of viruses replicates their RNA genomes using a core polymerase complex composed of viral non-structural proteins: nsp7, nsp8 and nsp12. Most of our understanding of coronavirus molecular biology comes from the betacoronaviruses like SARS-CoV and SARS-CoV-2, the latter of which is the causative agent of COVI...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f981bea7-df57-553d-bc5a-18bebe7dd603
DOI: 10.1101/2023.03.15.532841

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An alphacoronavirus polymerase structure reveals conserved co-factor functionsDOI 10.1101/2023.03.15.532841Read

An alphacoronavirus polymerase structure reveals conserved replication factor functionsSemantic proximity Read

A genus-specific nsp12 region impacts polymerase assembly in Alpha- and GammacoronavirusesSemantic proximity Read

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factorsSemantic proximity Read

Structure and function of SARS-CoV-2 polymeraseSemantic proximity Read

Hallmarks of <i>Alpha</i> - and <i>Betacoronavirus</i> non-structural protein 7+8 complexesSemantic proximity Read

The Life of SARS-CoV-2 Inside Cells: Replication–Transcription Complex Assembly and FunctionSemantic proximity Read

Conserved structures and dynamics in 5′-proximal regions of Betacoronavirus RNA genomesSemantic proximity Read

A structural and functional perspective of alphavirus replication and assemblySemantic proximity Read

Structure of the RNA-dependent RNA polymerase from COVID-19 virusSemantic proximity Read

Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug designSemantic proximity Read

Lessons Learned and Yet-to-Be Learned on the Importance of RNA Structure in SARS-CoV-2 ReplicationSemantic proximity Read

Structure and regulation of coronavirus genomes: state-of-the-art and novel insights from SARS-CoV-2 studiesSemantic proximity Read