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An alphacoronavirus polymerase structure reveals conserved replication factor functions

5 Mar 2024

Abstract excerpt

Coronaviruses are a diverse subfamily of viruses containing pathogens of humans and animals. This subfamily of viruses replicates their RNA genomes using a core polymerase complex composed of viral non-structural proteins: nsp7, nsp8 and nsp12. Most of our understanding of coronavirus molecular biology comes from betacoronaviruses like SARS-CoV and SARS-CoV-2, the latter of which is the causative agent of...

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PMID: 38442273
DOI: 10.1093/nar/gkae153

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