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A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent

21 May 2025

Abstract excerpt

Coronaviruses (CoVs) encode 16 nonstructural proteins (nsps), most of which form the replication-transcription complex (RTC). The RTC contains a core composed of one nsp12 RNA-dependent RNA polymerase (RdRp), two nsp8s, and one nsp7. The core RTC recruits other nsps to synthesize all viral RNAs within the infected cell. While essential for viral replication, the mechanism by which the core RTC assembles into a...

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PMID: 40464687
DOI: 10.1093/nar/gkaf450

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