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Microglial Responses to Alzheimer's Disease Pathology: Insights From “Omics” Studies

6 Jan 2025

Abstract excerpt

Human genetics studies lent firm evidence that microglia are key to Alzheimer's disease (AD) pathogenesis over a decade ago following the identification of AD-associated genes that are expressed in a microglia-specific manner. However, while alterations in microglial morphology and gene expression are observed in human postmortem brain tissue, the mechanisms by which microglia drive and contribute to AD pathology...

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PMID: 39760224
DOI: 10.1002/glia.24666

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