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Sex, not estrous cycle stage, drives differences in the microglial transcriptome in the 5xFAD mouse model of amyloidosis

2025-04-03

Abstract excerpt

Alzheimer’s disease (AD) presents with a sex bias where women are at higher risk and exhibit worse cognitive decline and brain atrophy compared to men. Microglia play a significant role in the pathogenesis and progression of AD and have been shown to be sexually differentiated in health and disease. Whether microglia contribute to the sex differences in AD remains to be elucidated. Herein, we characterize the sex...

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Literature Corpus work
bcd86479-87d1-53d8-8957-847cb4d313aa
DOI
10.1101/2025.03.28.646050
Open publication

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Sex, not estrous cycle stage, drives differences in the microglial transcriptome in the 5xFAD mouse model of amyloidosisDOI 10.1101/2025.03.28.646050
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