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Article

The Synergistic Effects of APOE Genotype and Obesity on Alzheimer’s Disease Risk

24 Dec 2018

Abstract excerpt

The APOE gene has three common alleles—E2, E3, and E4, with APOE4 being the strongest genetic risk factor for developing Alzheimer’s Disease (AD). Obesity is a global epidemic and contributes to multiple metabolic problems. Obesity is also a risk factor for cognitive decline. Here, we review the effects of APOE4 and obesity on cognition and AD development, independently and together. We describe studies that have...

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PMID: 30586872
DOI: 10.3390/ijms20010063

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