Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ApoE genotype accounts for the vast majority of AD risk and AD pathology.

Neurobiology of aging - 1 Jan 2000

Raber Jacob, Huang Yadong, Ashford J Wesson

Abstract excerpt

In this review, evidence is provided that apolipoprotein E (apoE) genotype accounts for the majority of Alzheimer's disease (AD) risk and pathology. The three major human isoforms, apoE2, apoE3, and apoE4, are encoded by different alleles (2, 3, 4) and regulate lipid metabolism and redistribution. ApoE isoforms differ in their effects on AD risk and pathology. Clinical and epidemiological data have indicated that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Alzheimer Disease
Share to Apolipoproteins E

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Memory Disorders

Share to Neurofibrillary Tangles

Share to Plaque, Amyloid

Share to Sex Factors

Source

Identifiers

PMID: 15172743
DOI: 10.1016/j.neurobiolaging.2003.12.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ApoE genotype accounts for the vast majority of AD risk and AD pathology.PMID 15172743Read ↗

APOE4 is a Risk Factor and Potential Therapeutic Target for Alzheimer's DiseaseSemantic proximity Read ↗

ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies.Semantic proximity Read ↗

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases.Semantic proximity Read ↗

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse modelsSemantic proximity Read ↗

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approachesSemantic proximity Read ↗

APOE and Alzheimer's Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer's Pathogenesis.Semantic proximity Read ↗

Apolipoprotein E and Alzheimer's diseaseSemantic proximity Read ↗

Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic StrategiesSemantic proximity Read ↗

Alzheimer's disease phenotype based upon the carrier status of the apolipoprotein E ɛ4 allele.Semantic proximity Read ↗

Apolipoprotein E and Alzheimer disease.Semantic proximity Read ↗

Impact of apolipoprotein E isoforms on sporadic Alzheimer’s diseaseSemantic proximity Read ↗

The multifaceted roles of apolipoprotein E4 in Alzheimer’s disease pathology and potential therapeutic strategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.