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APOE Alleles and Diet in Brain Aging and Alzheimer’s Disease

10 Jun 2020

Abstract excerpt

The APOE gene alleles modify human aging and the response to the diet at many levels with diverse pleotropic effects from gut to brain. To understand interactions of APOE isoforms and diet, we analyze how cellular trafficking of apoE proteins affects energy metabolism, the immune system and reproduction. The age-accelerating APOE4 allele alters endosomal trafficking of cell surface receptors that mediate lipid...

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PMID: 32587511
DOI: 10.3389/fnagi.2020.00150

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