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Article

The Impact of the Apolipoprotein E Genotype on Cardiovascular Disease and Cognitive Disorders.

Cardiology in review - 1 Jan 2026

McMaster Matthew W, Shah Avisha, Kangarlu John, Cheikhali Ryan, Frishman William H, Aronow Wilbert S

Abstract excerpt

Apolipoprotein E (ApoE) plays a critical role in cholesterol transport and protection against the development of atherosclerotic cardiovascular disease (ASCVD). Humans have 3 prevalent isoforms of ApoE: apolipoprotein E2 (ApoE2), apolipoprotein E3 (ApoE3), and apolipoprotein E4 (ApoE4). The E4 allele has been associated with higher ASCVD risk. While E4 patients do have higher cholesterol levels, they do not have...

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Identifiers

PMID: 38661359
DOI: 10.1097/CRD.0000000000000703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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