Effects of the ApoE genotype on cognitive function in aging mice fed with a high-fat diet and the protective potential of n-3 polyunsaturated fatty acids.

doi:10.1039/d3fo03965j

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Effects of the ApoE genotype on cognitive function in aging mice fed with a high-fat diet and the protective potential of n-3 polyunsaturated fatty acids.

Food & function - 19 Feb 2024

Zhang Xin, Xie Tianzhi, Zhou Shuang, Yuan Yingxuan, Chen Weixuan, Zheng Jie, Liu Xuebo, Yuan Tian, Lu Yanhui, Liu Zhigang

Abstract excerpt

The ApoE4 allele is the strongest genetic determinant for Alzheimer's disease (AD), while obesity is a strong environmental risk for AD. The modulatory effect of the ApoE genotype on aging-related cognitive function in tandem with a high-fat diet (HFD) remains uncertain. This study aimed to elucidate the effects of ApoE3/ApoE4 genotypes in aged mice exposed to a HFD, and the benefits of n-3 polyunsaturated fatty...

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