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Apolipoprotein E and Alzheimer's disease

16 Oct 2021

Abstract excerpt

Genetic variation in apolipoprotein E (APOE) influences Alzheimer's disease (AD) risk. APOE ε4 alleles are the strongest genetic risk factor for late onset sporadic AD. The AD risk is dose dependent, as those carrying one APOE ε4 allele have a 2–3-fold increased risk, while those carrying two ε4 alleles have a 10–15-fold increased risk. Individuals carrying APOE ε2 alleles have lower AD risk and those carrying...

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PMID: 35256931
DOI: 10.1016/j.apsb.2021.10.002

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