Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular signatures of X chromosome inactivation and associations with clinical outcomes in epithelial ovarian cancer.

Human molecular genetics - 15 Apr 2019

Winham Stacey J, Larson Nicholas B, Armasu Sebastian M, Fogarty Zachary C, Larson Melissa C, McCauley Brian M, Wang Chen, Lawrenson Kate, Gayther Simon, Cunningham Julie M, Fridley Brooke L, Goode Ellen L

Abstract excerpt

X chromosome inactivation (XCI) is a key epigenetic gene expression regulatory process, which may play a role in women's cancer. In particular tissues, some genes are known to escape XCI, yet patterns of XCI in ovarian cancer (OC) and their clinical associations are largely unknown. To examine XCI in OC, we integrated germline genotype with tumor copy number, gene expression and DNA methylation information from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Ovarian Epithelial
Share to Chromosomes, Human, X

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Genes, X-Linked

Share to Ovarian Neoplasms

Share to RNA, Long Noncoding

Share to X Chromosome Inactivation

Source

Open in PubMed Open full text

Identifiers

PMID: 30576442
DOI: 10.1093/hmg/ddy444
PMCID: PMC6625007

Genes

DDX3X
TCEANC
TRAPPC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular signatures of X chromosome inactivation and associations with clinical outcomes in epithelial ovarian cancer.PMID 30576442Read ↗

An integrative approach to assess X-chromosome inactivation using allele-specific expression with applications to epithelial ovarian cancer.Semantic proximity Read ↗

Defective X Chromosome Inactivation and Cancer Risk in WomenSemantic proximity Read ↗

Defective X-chromosome inactivation and cancer risk in womenSemantic proximity Read ↗

Analysis of expressed SNPs identifies variable extents of expression from the human inactive X chromosome.Semantic proximity Read ↗

Contribution of genetic and epigenetic changes to escape from X-chromosome inactivationSemantic proximity Read ↗

Reproducible autosomal gene expression changes with loss of typical X and Y complement across tumor typesSemantic proximity Read ↗

Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer.Semantic proximity Read ↗

Contribution of epigenetic changes to escape from X-chromosome inactivationSemantic proximity Read ↗

Landscape of X chromosome inactivation across human tissues.Semantic proximity Read ↗

Landscape of X chromosome inactivation across human tissuesSemantic proximity Read ↗

Genome-wide methylation profiling of ovarian cancer patient-derived xenografts treated with the demethylating agent decitabine identifies novel epigenetically regulated genes and pathwaysSemantic proximity Read ↗

Tumor specific methylome in Chinese high-grade serous ovarian cancer characterized by gene expression profile and tumor genotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.