Article
Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer.
Nature communications - 24 Apr 2020
Corona Rosario I, Seo Ji-Heui, Lin Xianzhi, Hazelett Dennis J, Reddy Jessica, Fonseca Marcos A S, Abassi Forough, Lin Yvonne G, Mhawech-Fauceglia Paulette Y, Shah Sohrab P, Huntsman David G, Gusev Alexander, Karlan Beth Y, Berman Benjamin P, Freedman Matthew L, Gayther Simon A, Lawrenson Kate
Abstract excerpt
The functional consequences of somatic non-coding mutations in ovarian cancer (OC) are unknown. To identify regulatory elements (RE) and genes perturbed by acquired non-coding variants, here we establish epigenomic and transcriptomic landscapes of primary OCs using H3K27ac ChIP-seq and RNA-seq, and then integrate these with whole genome sequencing data from 232 OCs. We identify 25 frequently mutated regulatory...
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