Article
An integrative approach to assess X-chromosome inactivation using allele-specific expression with applications to epithelial ovarian cancer.
Genetic epidemiology - 1 Dec 2017
Larson Nicholas B, Fogarty Zachary C, Larson Melissa C, Kalli Kimberly R, Lawrenson Kate, Gayther Simon, Fridley Brooke L, Goode Ellen L, Winham Stacey J
Abstract excerpt
X-chromosome inactivation (XCI) epigenetically silences transcription of an X chromosome in females; patterns of XCI are thought to be aberrant in women's cancers, but are understudied due to statistical challenges. We develop a two-stage statistical framework to assess skewed XCI and evaluate gene-level patterns of XCI for an individual sample by integration of RNA sequence, copy number alteration, and genotype...
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