Article

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface

2023-12-14

Abstract excerpt

Influenza infection and vaccination impart strain-specific immunity that protects against neither seasonal antigenic variants nor the next pandemic. However, antibodies directed to conserved sites can confer broad protection. Here we identify and characterize a class of human antibodies that engage a previously undescribed, conserved epitope on the influenza hemagglutinin (HA) protein. Prototype antibody S8V1-157...

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Literature Corpus work: 20a0a122-dcc4-5b77-a117-d7a62a3857d5
DOI: 10.1101/2023.12.13.571543

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