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Article

Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses.

Science (New York, N.Y.) - 19 Jun 2020

Wu Nicholas C, Thompson Andrew J, Lee Juhye M, Su Wen, Arlian Britni M, Xie Jia, Lerner Richard A, Yen Hui-Ling, Bloom Jesse D, Wilson Ian A

Abstract excerpt

The discovery and characterization of broadly neutralizing human antibodies (bnAbs) to the highly conserved stem region of influenza hemagglutinin (HA) have contributed to considerations of a universal influenza vaccine. However, the potential for resistance to stem bnAbs also needs to be more thoroughly evaluated. Using deep mutational scanning, with a focus on epitope residues, we found that the genetic barrier...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

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Share to Immunodominant Epitopes

Share to Influenza A Virus, H1N1 Subtype

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Source

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Identifiers

PMID: 32554590
DOI: 10.1126/science.aaz5143
PMCID: PMC7412937

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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