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Article

Diversity of antigenic mutants of influenza A(H1N1)pdm09 virus escaped from human monoclonal antibodies.

Scientific reports - 18 Dec 2017

Yasuhara Atsuhiro, Yamayoshi Seiya, Soni Priyanka, Takenaga Toru, Kawakami Chiharu, Takashita Emi, Sakai-Tagawa Yuko, Uraki Ryuta, Ito Mutsumi, Iwatsuki-Horimoto Kiyoko, Sasaki Tadahiro, Ikuta Kazuyoshi, Yamada Shinya, Kawaoka Yoshihiro

Abstract excerpt

Since the 2017 Southern Hemisphere influenza season, the A(H1N1)pdm09-like virus recommended for use in the vaccine was changed because human, but not ferret, sera distinguish A(H1N1)pdm09 viruses isolated after 2013 from the previously circulating strains. An amino acid substitution, lysine to glutamine, at position 166 (H3 numbering) in the major antigenic site of HA was reported to be responsible for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemagglutinin Glycoproteins, Influenza Virus

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Identifiers

PMID: 29255273
DOI: 10.1038/s41598-017-17986-8
PMCID: PMC5735164

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