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Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodies

23 Apr 2025

Abstract excerpt

Monoclonal antibodies (mAbs) targeting the influenza hemagglutinin (HA) can be used as prophylactics or templates for next-generation vaccines. Here, we isolated broad, subtype-neutralizing mAbs from human B cells recognizing the H1 or H3 HA "head" and a mAb engaging the conserved stem. The H1 mAbs bind the lateral patch epitope on HAs from 1933 to 2021 and a prepandemic swine H1N1 virus. We improved...

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PMID: 40267182
DOI: 10.1126/sciadv.adu9140

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