Article
Resistance Mutations to Broadly Neutralizing Antibodies Destabilize Hemagglutinin and Attenuate H1N1 Influenza Virus.
Viruses - 24 Dec 2025
Yang Guohua, Chen Po-Ling, Rovito Samuel W, Minari Karine, Writt Haley N, DeBeauchamp Jennifer, Crumpton Jeri Carol, Kercher Lisa, DuBois Rebecca M, Webby Richard J, Russell Charles J
Abstract excerpt
Because antigenic drift primarily generates amino-acid changes in the membrane-distal hemagglutinin (HA) head, broadly neutralizing antibodies (bNAbs) are being developed to target conserved epitopes in the membrane-proximal stem. Mutations to HA2 residue A44, a buried residue beneath the central stem epitope, in 2009 H1N1 viruses have been shown to cause resistance to stem-binding bNAbs. Here, we introduced A44V...
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