Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

24 Aug 2015

Abstract excerpt

The identification of human broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin (HA) stem revitalized hopes of developing a universal influenza vaccine. Using a rational design and library approach, we engineered stable HA stem antigens ("mini-HAs") based on an H1 subtype sequence. Our most advanced candidate exhibits structural and bnAb binding properties comparable to those of full-length HA,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Influenza Virus Research Studies
Share to Respiratory viral infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26303961
DOI: 10.1126/science.aac7263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogenPMID 26303961Read ↗

Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody LineagesSemantic proximity Read ↗

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interfaceSemantic proximity Read ↗

Structure basis for distinct protective mechanisms of IGHV3-23 antibodies targeting influenza hemagglutinin stemSemantic proximity Read ↗

Vaccination with different group 2 influenza subtypes alters epitope targeting and breadth of hemagglutinin stem–specific human B cellsSemantic proximity Read ↗

A small-molecule fusion inhibitor of influenza virus is orally active in miceSemantic proximity Read ↗

Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodiesSemantic proximity Read ↗

H5N1 Vaccine–Elicited Memory B Cells Are Genetically Constrained by the IGHV Locus in the Recognition of a Neutralizing Epitope in the Hemagglutinin StemSemantic proximity Read ↗

A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response.Semantic proximity Read ↗

Preferential induction of cross-group influenza A hemagglutinin stem–specific memory B cells after H7N9 immunization in humansSemantic proximity Read ↗

Mapping of a Novel H3-Specific Broadly Neutralizing Monoclonal Antibody Targeting the Hemagglutinin Globular Head Isolated from an Elite Influenza Virus-Immunized Donor Exhibiting Serological BreadthSemantic proximity Read ↗

A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus HemagglutininSemantic proximity Read ↗

The pre-existing human antibody repertoire to computationally optimized influenza H1 hemagglutinin vaccinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.