Article
Polygenic risk score analyses of symptoms and treatment response in an antipsychotic-naive first episode of psychosis cohort.
Translational psychiatry - 31 Aug 2018
Santoro Marcos Leite, Ota Vanessa, de Jong Simone, Noto Cristiano, Spindola Leticia M, Talarico Fernanda, Gouvea Eduardo, Lee Sang Hyuck, Moretti Patricia, Curtis Charles, Patel Hamel, Newhouse Stephen, Carvalho Carolina Muniz, Gadelha Ary, Cordeiro Quirino, Bressan Rodrigo Affonseca, Belangero Sintia Iole, Breen Gerome
Abstract excerpt
In this study, we aimed to test if the schizophrenia (SCZ) polygenic risk score (PRS) was associated with clinical symptoms in (a) the first episode of psychosis pre-treatment (FEP), (b) at nine weeks after initiation of risperidone treatment (FEP-9W) and (c) with the response to risperidone. We performed a detailed clinical assessment of 60 FEP patients who were antipsychotic-naive and, again, after nine weeks...
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