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Article

Prediction of antipsychotics efficacy based on a polygenic risk score: a real-world cohort study

8 Mar 2024

Abstract excerpt

Background: Response to antipsychotics is subject to a wide interindividual variability, due to genetic and non-genetic factors. Several single nucleotide polymorphisms (SNPs) have been associated with response to antipsychotics in genome-wide association studies (GWAS). Polygenic risk scores (PRS) are a powerful tool to aggregate into a single measure the small effects of multiple risk alleles. Materials and...

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PMID: 38523642
DOI: 10.3389/fphar.2024.1274442

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