Article
Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study.
Psychological medicine - 1 Jun 2023
Rodriguez Victoria, Alameda Luis, Quattrone Diego, Tripoli Giada, Gayer-Anderson Charlotte, Spinazzola Edoardo, Trotta Giulia, Jongsma Hannah E, Stilo Simona, La Cascia Caterina, Ferraro Laura, La Barbera Daniele, Lasalvia Antonio, Tosato Sarah, Tarricone Ilaria, Bonora Elena, Jamain Stéphane, Selten Jean-Paul, Velthorst Eva, de Haan Lieuwe, Llorca Pierre-Michel, Arrojo Manuel, Bobes Julio, Bernardo Miguel, Arango Celso, Kirkbride James, Jones Peter B, Rutten Bart P, Richards Alexander, Sham Pak C, O'Donovan Michael, Van Os Jim, Morgan Craig, Di Forti Marta, Murray Robin M, Vassos Evangelos
Abstract excerpt
BACKGROUND: Schizophrenia (SZ), bipolar disorder (BD) and depression (D) run in families. This susceptibility is partly due to hundreds or thousands of common genetic variants, each conferring a fractional risk. The cumulative effects of the associated variants can be summarised as a polygenic risk score (PRS). Using data from the EUropean Network of national schizophrenia networks studying Gene-Environment...
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