An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis.

doi:10.1016/j.biopsych.2016.06.028

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Article

An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis.

Biological psychiatry - 15 Mar 2017

Vassos Evangelos, Di Forti Marta, Coleman Jonathan, Iyegbe Conrad, Prata Diana, Euesden Jack, O'Reilly Paul, Curtis Charles, Kolliakou Anna, Patel Hamel, Newhouse Stephen, Traylor Matthew, Ajnakina Olesya, Mondelli Valeria, Marques Tiago Reis, Gardner-Sood Poonam, Aitchison Katherine J, Powell John, Atakan Zerrin, Greenwood Kathryn E, Smith Shubulade, Ismail Khalida, Pariante Carmine, Gaughran Fiona, Dazzan Paola, Markus Hugh S, David Anthony S, Lewis Cathryn M, Murray Robin M, Breen Gerome

Abstract excerpt

BACKGROUND: Polygenic risk scores (PRSs) have successfully summarized genome-wide effects of genetic variants in schizophrenia with significant predictive power. In a clinical sample of first-episode psychosis (FEP) patients, we estimated the ability of PRSs to discriminate case-control status and to predict the development of schizophrenia as opposed to other psychoses. METHODS: The sample (445 case and 265...

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PMID: 27765268
DOI: 10.1016/j.biopsych.2016.06.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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