Article
Redefining synchronous colorectal cancers based on tumor clonality.
International journal of cancer - 1 Apr 2019
Perea José, García Juan L, Corchete Luis, Lumbreras Eva, Arriba María, Rueda Daniel, Tapial Sandra, Pérez Jessica, Vieiro Victoria, Rodríguez Yolanda, Brandáriz Lorena, García-Arranz Mariano, García-Olmo Damián, Goel Ajay, Urioste Miguel, Sarmiento Rogelio González
Abstract excerpt
To analyze the possible clonal origin of a part of Synchronous colorectal cancer (SCRC), we studied 104 paired-SCRCs from 52 consecutive patients without hereditary forms of CRC. We used a Single-Nucleotide Polymorphism array to characterize the genomic profiles, and subsequently used a statistical application to define them according to clonality within the same individual. We categorized the ensuing groups...
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