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Article

Discordance of p53 mutations of synchronous colorectal carcinomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2000

Eguchi K, Yao T, Konomoto T, Hayashi K, Fujishima M, Tsuneyoshi M

Abstract excerpt

It is unclear whether synchronous multiple tumors arise from multicentric or monoclonal origins. To verify the multicentric origin of synchronous colorectal carcinomas at a genetic level, immunohistochemical and molecular techniques were used to determine the p53 alterations in individual lesions of synchronous colorectal carcinomas. This study was based on a total of 32 colorectal tumors from 16 patients....

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Identifiers

PMID: 10697269
DOI: 10.1038/modpathol.3880024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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