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Article

Genetic heterogeneity in synchronous colorectal cancers impacts genotyping approaches and therapeutic strategies.

Genes, chromosomes & cancer - 1 Mar 2016

Jesinghaus Moritz, Pfarr Nicole, Kloor Matthias, Endris Volker, Tavernar Luca, Muckenhuber Alexander, von Knebel Doeberitz Magnus, Penzel Roland, Weichert Wilko, Stenzinger Albrecht

Abstract excerpt

Synchronous colorectal carcinomas (sCRC) are clinically challenging neoplasms. Although the epidemiological characteristics are quite well established, their biological basis is still poorly understood. Hence, we performed comprehensive molecular profiling of 23 sCRC cases comprising 50 synchronous primary tumors, 5 metastases, and corresponding normal tissue by targeted deep sequencing of 30 CRC-related genes,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26650777
DOI: 10.1002/gcc.22330

Genes

KRAS
APC
MLH1
TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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