Clonal relationship and directionality of progression of synchronous endometrial and ovarian carcinomas in patients with DNA mismatch repair-deficiency associated syndromes.

doi:10.1038/s41379-020-00721-6

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Article

Clonal relationship and directionality of progression of synchronous endometrial and ovarian carcinomas in patients with DNA mismatch repair-deficiency associated syndromes.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2021

Moukarzel Lea A, Da Cruz Paula Arnaud, Ferrando Lorenzo, Hoang Timothy, Sebastiao Ana Paula Martins, Pareja Fresia, Park Kay J, Jungbluth Achim A, Capella Gabriel, Pineda Marta, Levin Jeffrey D, Abu-Rustum Nadeem R, Ellenson Lora H, Bel August Vidal, Reis-Filho Jorge S, Matias-Guiu Xavier, Cadoo Karen, Stadler Zsofia K, Weigelt Britta

Abstract excerpt

Sporadic synchronous endometrial (ECs) and ovarian cancers (OCs), although clinically considered to be independent primaries, have been shown to be clonally related and likely constitute metastases from each other. We sought to define whether synchronous ECs/OCs in patients with DNA mismatch repair (MMR)-deficiency syndromes would be clonally related. We subjected synchronous ECs/OCs from four patients (LS3-LS6)...

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PMID: 33328602
DOI: 10.1038/s41379-020-00721-6
PMCID: PMC8076061

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