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Article

Double PIK3CA Alterations and Parallel Evolution in Colorectal Cancers.

American journal of clinical pathology - 3 Feb 2022

Lin Ming-Tseh, Zheng Gang, Rodriguez Erika, Tseng Li-Hui, Parini Vamsi, Xian Rena, Zou Ying, Gocke Christopher D, Eshleman James R

Abstract excerpt

OBJECTIVES: To demonstrate clinicopathologic features and evaluate the clonality of double PIK3CA alterations in colorectal cancers (CRCs). METHODS: Clonality was examined in 13 CRCs with double PIK3CA alterations (1.7% of CRCs or 9.6% of PIK3CA-mutated CRCs). Multiregional analyses were performed to confirm subclonal PIK3CA alterations. RESULTS: PIK3CA alterations were detected within exon 9 (51%), exon 20...

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PMID: 34519764
DOI: 10.1093/ajcp/aqab119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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