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Article

Clonal and "Intrinsic" Heterogeneity of Somatic Variants in Microsatellite-Stable Colorectal Carcinomas and Their Metastases.

Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2023

Hühns Maja, Ameziane Najim, Holzmann Carsten, Al-Ali Ruslan, Prall Friedrich

Abstract excerpt

To test the traditional model of tumor progression, Darwinian-type evolution, against the more recent Big Bang model, we selected 6 microsatellite-stable colorectal standard-type adenocarcinomas and their synchronous lymph node and liver metastases. Somatic genomic variants were identified by whole-exome sequencing (WES) of large tumor fragments from the primaries and 1 liver metastasis each, and used to design...

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PMID: 36966951
DOI: 10.1016/j.labinv.2023.100132

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