Article
Many colorectal cancers are "flat" clonal expansions.
Cell cycle (Georgetown, Tex.) - 15 Jul 2009
Siegmund Kimberly D, Marjoram Paul, Tavaré Simon, Shibata Darryl
Abstract excerpt
Population geneticists can reconstruct the ancestries of macroscopic populations from polymorphisms in present day individuals. For example, the migration "out of Africa" is recorded in human genome variation in different parts of the world. Here we apply this approach to human colorectal cancer cell populations and polymorphic passenger methylation patterns. By sampling molecular variation from different parts...
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