Article
Synchronous colon carcinomas: molecular-genetic evidence for multicentricity.
Annals of surgical oncology - 1 Mar 1996
Koness R J, King T C, Schechter S, McLean S F, Lodowsky C, Wanebo H J
Abstract excerpt
BACKGROUND: The synchronous presentation of multiple colonic adenocarcinomas is an unusual, but well-recognized event accounting for approximately 2-11% of these neoplasms. Synchronous tumors may have a different biology and prognosis than solitary tumors. Evidence based on measurement of DNA ploidy suggests that a significant percentage of synchronous tumors have a common clonal origin, probably resulting from...
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