Article
Many are called but few are chosen – Multiple clonal origins greatly elevate the functional heterogeneity of tumors
2020-09-01
Abstract excerpt
Each tumor is usually accepted to be of a single origin from a progenitor cell. The shared evolutionary paths impose a limit on the nature of genetic diversity of the tumor. However, there are also numerous stem cell niches with independent proliferation potentials. To reconcile the contrasting perspectives, we propose a model whereby each tumor is of multiple clonal origins but the most proliferative one would ec...
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Identifiers and source
- Literature Corpus work
- 76fd803f-586e-5a9b-b886-d451a86e7fbb
- DOI
- 10.1101/2020.09.01.277848