Article
The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten.
PLoS genetics - 1 Aug 2018
Liang Xiaohuan, Daikoku Takiko, Terakawa Jumpei, Ogawa Yuya, Joshi Ayesha R, Ellenson Lora H, Sun Xiaofei, Dey Sudhansu K
Abstract excerpt
Mutation of the tumor suppressor Pten often leads to tumorigenesis in various organs including the uterus. We previously showed that Pten deletion in the mouse uterus using a Pgr-Cre driver (Ptenf/fPgrCre/+) results in rapid development of endometrial carcinoma (EMC) with full penetration. We also reported that Pten deletion in the stroma and myometrium using Amhr2-Cre failed to initiate EMC. Since the...
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