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Article

Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice.

Gynecologic oncology - 1 Feb 2008

Fyles Anthony, Wood Geoffrey, Li Ming, Manoukian Armen S, Gowing Katrina, Khokha Rama, Chapman William, Tsao Ming-Sound

Abstract excerpt

OBJECTIVE: Hormonal therapy for type I (endometrioid) endometrial carcinoma is employed as both a conservative treatment option and for advanced or recurrent disease, but outcome is often poor. Our objective was to test whether ovariectomy, or ovariectomy followed by progestin treatment prevents...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18048091
DOI: 10.1016/j.ygyno.2007.10.033

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18048091-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice.PMID 18048091Read ↗

Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice.Semantic proximity Read ↗

PI3K/PTEN/AKT Genetic Mouse Models of Endometrial Carcinoma.Semantic proximity Read ↗

Activated mutant p110α causes endometrial carcinoma in the setting of biallelic Pten deletion.Semantic proximity Read ↗

Altered PTEN Expression as a Diagnostic Marker for the Earliest Endometrial PrecancersSemantic proximity Read ↗

The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten.Semantic proximity Read ↗

Lean Body Weight and Metformin Are Insufficient to Prevent Endometrial Hyperplasia in Mice Harboring Inactivating Mutations in PTEN.Semantic proximity Read ↗

Akt-Mediated Phosphorylation and Activation of Estrogen Receptor α Is Required for Endometrial Neoplastic Transformation in <i>Pten</i>+/− MiceSemantic proximity Read ↗

The Synergistic Effect of Conditional<i>Pten</i>Loss and Oncogenic<i>K-ras</i>Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor ActionSemantic proximity Read ↗

Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes.Semantic proximity Read ↗

Changes in Endometrial<i>PTEN</i>Expression throughout the Human Menstrual Cycle<sup>1</sup>Semantic proximity Read ↗

Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activitiesSemantic proximity Read ↗

Conditional abrogation of transforming growth factor-β receptor 1 in PTEN-inactivated endometrium promotes endometrial cancer progression in mice.Semantic proximity Read ↗

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